of the 64 spells in jewO.. theres only about 24 worth setting a macros for - the rest should be run off the icons
and if we are talking about all pvp related macro's there's only another dozen macros needed to cover pots, pouches, bandaids, skills, targets (self, last, next, closest red/blue/friend etc.), & arm/disarm weps etc.
and I dont know anything about having to reach across the key board for any macros... I never used the numpad or F keys like a lot of people.
My set up uses shift/ctrl/alt + 1-4, Q-R, A-F, & Z-V... and my left hand never leaves the 'zone' - I treat it like I'm playing an FPS (I do have a bad ass mouse that I keep a bunch of macro's on though)
If your really leet tho you could be like Max & Murd doing the whole split key board and mouse thing.. that shit was hillarious to watch them PvP & talk shit @ full speed
People would freak out like 'how the fuck is this guy running, casting, shooting, and typing up a full conversation all at the same time.. Hacks!?!'